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Official Title
Phase II Randomized Trial of Neo-Adjuvant Chemotherapy Followed by Surgery and Post-Operative Radiation Versus Surgery and Post-Operative Radiation for Organ Preservation of T3 and T4a Nasal and Paranasal Sinus Squamous Cell Carcinoma (NPNSCC)
Phase
Phase 2
Sponsor
ECOG-ACRIN Cancer Research Group
Enrollment
82
Timeline
Mar 2019 → Mar 2029
About This Study
This randomized phase II trial studies how well chemotherapy before surgery and radiation therapy works compared to surgery and radiation therapy alone in treating patients with nasal and paranasal sinus cancer that can be removed by surgery. Drugs used in chemotherapy, such as docetaxel, cisplatin, and carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving chemotherapy before surgery and radiation therapy may make the tumor smaller and reduce the amount of normal tissue that needs to be removed and treated with radiation.
Eligibility Criteria
Inclusion Criteria
- 1Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- 2General physical condition compatible with the proposed chemotherapy and surgery
- 3Stage T3 or T4a, histologically-confirmed NPNSCC requiring orbital or skull base resection:
- 4Stages T3 and T4a disease will be included regardless of nodal status (N0 or N1-3), provided that surgical therapy would require orbital or skull base resection
- 5The surgical oncologist in each institution will determine the need for resection of the orbit OR base of skull at baseline for patients on both Arms A and B and following neo-adjuvant chemotherapy for patients on Arm B
- 6Resection of skull base will be deemed necessary according to skull base bone erosion by CT or marrow involvement by MRI is noted; for any disease abutting the skull base; or for ethmoid sinus or frontal sinus involvement
- 7Resection of orbital contents will be deemed necessary according to skull base society guidelines, based on involvement of periorbital fat documented by MRI imaging
- 8Patients must be deemed surgically resectable by the surgical teams at each institution and must have a determination of degree of anticipated structure preservation of orbit and skull base; this needs to be determined prior to randomization
- 9Patients may not be receiving investigational agents at time of registration, or at any time while on study and during the 4 weeks preceding enrollment
- 10Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to docetaxel and/or both platinum-based chemotherapy agents are excluded; patient must be able to receive at least one of the two proposed chemotherapy regimens
- 11Patients with evidence of distant metastases or leptomeningeal disease (LMD) are excluded
- 12Patients must not have received previous irradiation for head and neck tumor, skull base, or brain tumors
- 13Patients with uncontrolled inter-current illnesses which in the opinion of the investigator will interfere with the ability to undergo therapy including chemotherapy are excluded
- 14Patients with a history of a different malignancy are excluded, unless the disease has not progressed for \>= 2 years
- 15Absolute neutrophil count (ANC) \> 1500/mm\^3 =\< 2 weeks prior to randomization
- 16Hemoglobin (Hgb) \> 8.0 g/dL =\< 2 weeks prior to randomization
- 17Platelet count \> 100,000/mm\^3 =\< 2 weeks prior to randomization
- 18Creatinine clearance of \> 60 ml/min; creatinine clearance may be measured or calculated; if calculating, creatinine clearance, use the Cockroft-Gault formula =\< 2 weeks prior to randomization
- 19Total bilirubin within normal limits (must be obtained =\< 2 weeks prior to randomization)
- 20Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) must be within the range allowing for eligibility, must be obtained \< 2 weeks prior to randomization
- 21Alkaline phosphatase must be within the range allowing for eligibility, must be obtained \< 2 weeks prior to randomization
- 22Patients with a prior history of squamous cell or basal carcinoma of the skin or in situ cervical cancer must have been curatively treated
- 23No current peripheral neuropathy \> grade 2 at time of randomization
- 24Patients must not have any co-existing condition that would preclude full compliance with the study; no prior history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80
- 25Women must not be pregnant or breast-feeding
- 26All females of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy
- 27A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- 28Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study
- 29Patients must have measurable disease; MRI and/or PET/CT scans need to be performed within 2 weeks prior to registration
Locations
140 sites participating in this study
Emory Proton Therapy Center
Atlanta, Georgia 30308
Dong M. Shin
Emory University Hospital Midtown
Atlanta, Georgia 30308
Dong M. Shin
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia 30322
Dong M. Shin
Data sourced from ClinicalTrials.govView on ClinicalTrials.gov →