Trial Filter
BETAAn intelligent search tool for clinical trials
Official Title
Phase II Evaluation of the Effect of 2 Versus 6 Hour Oxaliplatin Infusions on Neuropathy and Pharmacokinetics in Patients With Gastrointestinal Cancers
Phase
Phase 2
Sponsor
Emory University
Enrollment
60
Timeline
Mar 2019 → Sep 2026
About This Study
This phase II trial studies how well giving oxaliplatin over 6 hours works in treating nerve damage in patients with gastrointestinal cancers. Oxaliplatin can cause side effects such as nerve damage that may delay or reduce the dose of oxaliplatin. Giving oxaliplatin over a longer period of time (6 hours) may prevent or delay the development of nerve damage, which may keep patients on standard doses of chemotherapy longer, without having to delay treatment.
Eligibility Criteria
Inclusion Criteria
- 1Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- 2Confirmed diagnosis of a gastrointestinal cancer
- 3Plan for 4 or more cycles of FOLFOX6 (fluorouracil \[with leucovorin\] and oxaliplatin) containing chemotherapy
- 4Histologically confirmed, measurable or evaluable disease. Patients with advanced or metastatic disease should have at least one measurable lesion by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. Patients in the adjuvant treatment setting planned to have \> 4 cycles of FOLFOX-containing chemotherapy are eligible and will be followed per standard of care
- 5Absolute neutrophil count (ANC) ≥ 1,500/µL (no white blood cell growth factors allowed to meet requirement)
- 6Platelets ≥ 75,000/µL (may be transfused up to 72 hours prior to day 1 to meet requirement)
- 7Hemoglobin ≥ 8 g/dL (may be transfused up to 72 hours prior to day 1 to meet requirement)
- 8Creatinine clearance \> 30 mL/min by Cockcroft-Gault, to preserve similar dosing (85 mg/m²) for analysis
- 9Total bilirubin ≤ 1.5 x upper limit of normal (ULN)
- 10Signed informed consent
- 11Adequate birth control when appropriate
Exclusion Criteria
- 1Any preexisting grade 2 or higher peripheral neuropathy
- 2Patients currently receiving anticancer therapies or who have received any focal or systemic anticancer therapy within 14days of the start of FOLFOX6
- 3Known intolerance or hypersensitivity to any agent in FOLFOX6 or concurrent agents
- 4Patients who have any known severe and/or uncontrolled medical conditions such as:
- 5Unstable angina pectoris, symptomatic heart failure; (New York Heart Association class III or IV), myocardial infarction ≤ 6 months prior, serious uncontrolled cardiac arrhythmia, or any other clinically significant cardiac disease
- 6Active (acute or chronic) or uncontrolled severe infection, liver disease such as cirrhosis, or decompensated liver disease
- 7Patients with any history of severe hemorrhage requiring ≥ 4 units of packed red blood cells (RBCs) in a 48-hour period
- 8Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study
- 9Patients who are currently part of or have participated in any clinical investigation with an investigational drug within 14days prior to dosing
- 10Pregnant or nursing (lactating) women
- 11Women of childbearing potential (WOCBP), defined as all women physiologically capable of becoming pregnant, must use highly effective methods of contraception during the study and 8 weeks after. Highly effective contraception methods include combination of any two of the following:
- 12Use of oral, injected or implanted hormonal methods of contraception or;
- 13Placement of an intrauterine device (IUD) or intrauterine system (IUS);
- 14Barrier methods of contraception: condom or occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/ vaginal suppository;
- 15Total abstinence or;
- 16Male/female sterilization Women are considered post-menopausal and not of childbearing potential if they have had 12 months of natural (spontaneous) amenorrhea with an appropriate clinical profile (e.g. age appropriate, history of vasomotor symptoms) or have had surgical bilateral oophorectomy (with or without hysterectomy) or tubal ligation at least six weeks prior to randomization. In the case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment is she considered not of childbearing potential
Locations
3 sites participating in this study
Emory University Hospital Midtown
Atlanta, Georgia 30308
Olumide B. Gbolahan, MBBS, MSc
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia 30322
Olumide B. Gbolahan, MBBS, MSc
Emory Saint Joseph's Hospital
Atlanta, Georgia 30342
Olumide B. Gbolahan, MBBS, MSc
Data sourced from ClinicalTrials.govView on ClinicalTrials.gov →