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Official Title
An Open Label Evaluation Phase 1 Trial of the Safety and Pharmacokinetics of MRX-2843 in Adolescents and Adults with Relapsed/Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Mixed Phenotype Acute Leukemia
Phase
Phase 1
Sponsor
Meryx, Inc.
Enrollment
50
Timeline
Apr 2022 → Mar 2026
About This Study
This is a Phase I, open-label, non-randomized, dose escalation study in adolescents and adults with relapsed/refractory acute myeloid leukemia, acute lymphoblastic leukemia, or mixed phenotype acute leukemia. Patients will receive continuous oral MRX-2843 in 28 day cycles at predefined dose cohorts.
Eligibility Criteria
Inclusion Criteria
- 1Patient is a male or female at least 12 years of age.
- 2Patient must weigh at least 40 Kg.
- 3Patient has histologically or cytologically confirmed diagnosis of AML as defined by the World Health Organization (WHO) criteria (2017), ALL, or MPAL and is in second or later relapse or is refractory to at least one induction regimen.
- 4The effects of MRX-2843 on developing human fetus are unknown. For this reason, women of child-bearing potential and men must agree to remain abstinent, or agree to practice double barrier forms of birth control in which 2 of the following precautions are used during the study and for 4 months after last dose of study drug(s): vasectomy, tubal ligation (or other transcervical sterilization procedures), vaginal diaphragm, intrauterine device, birth control pills, birth control implant, or condom or sponge with spermicide.
- 5Female patients of childbearing potential must be nonpregnant, nonlactating, and have a negative pregnancy test result at Screening and a negative pregnancy test on Day 1 of Cycles 1-4.
- 6Patient is able to provide written, informed consent or assent for patients \< 18 years of age is provided along with parent/guardian consent before initiation of any study related procedures, and patient is able, in the opinion of the investigator, to comply with all the requirements of the study.
- 7Patient is able to swallow oral medication.
- 8Patient has white blood cell (WBC) lower than 25,000/mm3 at Screening prior to initiation of MRX-2843. Patients who are otherwise medically eligible for enrollment but have WBC above 25,000/mm3 are allowed concurrent treatment with hydroxyurea to stabilize the WBC. In these situations, hydroxyurea will be discontinued once WBC is below 10,000/mm3 and at least 1 day prior to start of study treatment. Treatment with hydroxyurea will be allowed during Cycle 1 if deemed needed by the Investigator.
- 9The Patient has laboratory values at Screening:
- 10Bilirubin ≤ 1.5 the upper limit of normal (ULN). For patients with documented Gilbert's disease, bilirubin ≤ 3.0 mg/dL
- 11Creatinine clearance (CrCl) ≥ 60 mL/min. For creatinine clearance estimation, the Cockcroft and Gault equation should be used:
- 12Male: CrCl (mL/min) = (140 - age) × wt (kg) / (serum creatinine × 72) (For females: Multiply above result by 0.85)
- 13Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3.0 × ULN
- 14Patient has Eastern Cooperative Oncology Group (ECOG) performance status 0-2 or Lansky/Karnofsky ≥ 50.
- 15For the FLT3ITD expansion cohort at RP2D, the FLT3ITD+ patients should have previously been treated with at least one FLT3 inhibitor prior to enrollment.
- 16Patient has not fully recovered from acute toxic effects due to all prior therapies, except alopecia and other non-clinically significant AEs prior to enrollment.
- 17Patient has active clinically significant GvHD.
- 18Patient has received calcineurin inhibitors within four weeks of study treatment.
- 19Patient is known to have human immunodeficiency virus infection (HIV).
- 20Patient has used a small molecular kinase inhibitor or any investigational drug or product within 28 days or 5 half lives, whichever is longer, before study drug dosing.
- 21Patient has a diagnosis of active hepatitis B or C.
- 22Patient has an active uncontrolled infection.
- 23Patient has a history of Type 1 Diabetes (T1D) or is considered at high risk for T1D, where high risk is defined as
- 24Patient has 1 first-degree relative (FDR; defined as parents, offspring or siblings) with T1D AND A1C value \> 6.5% or
- 25Patient has 2+FDR with T1D
- 26Patient has known or suspected history of retinitis pigmentosa or known or suspected familial history of retinitis pigmentosa.
- 27Patient requires concomitant treatment, in therapeutic doses, with anticoagulants such as warfarin or coumadin-related agents, thrombin or FXa inhibitors, and antiplatelet agents (e.g., clopidogrel). Low dose aspirin (≤ 81 mg/day), low-dose warfarin (≤1 mg/day), and prophylactic Low Molecular Weight Heparin (LMWH) are permitted.
- 28Patient has congestive heart failure New York Heart Association (NYHA) class 3 or 4, or patient with a history of congestive heart failure NYHA class 3 or 4 in the past, unless a screening echocardiogram performed within 3 months prior to study entry results in a left ventricular ejection fraction that is ≥ 45%.
- 29Patient has QTcF \> 480 ms.
- 30Patient has had major surgery within 4 weeks of the first dose of study drug.
- 31The patient is unable or unwilling to abide by the study protocol or cooperate fully with the investigator or designee.
Exclusion Criteria
- 1To be eligible for this study, each of the following criteria must be satisfied with a "NO" answer:
- 2All Subjects:
- 3Patient has diagnosis of acute promyelocytic leukemia (or AML M3).
- 4Patients with known active CNS leukemia.
- 5Patient has any surgical or medical condition (active or chronic) that may interfere with drug absorption, distribution, metabolism, or excretion of the study drug, or any other condition that may place the patient at risk.
- 6Patient has a history of other malignancies that have required systemic treatment within the last 2 years or are deemed by the investigator to have a potential to interfere with the safety and efficacy assessment of MRX2843. Patients with treated nonmelanoma skin cancer, in situ carcinoma or cervical intraepithelial neoplasia, regardless of the disease-free duration, are eligible for this study if definitive treatment for the condition has been completed.
- 7Patient has received radionuclide treatment within 6 weeks of the first dose of study treatment.
Locations
3 sites participating in this study
Emory University - WINSHIP Cancer Center
Atlanta, Georgia 30322
William Blum, MD
Emory University, Children's Healthcare of Atlanta
Atlanta, Georgia 30322
Melinda Pauly, MD
Memorial Sloan Kettering Cancer Center
New York, New York 10065
Dr. Neerav Shukla
Data sourced from ClinicalTrials.govView on ClinicalTrials.gov →