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Official Title

A Phase I First-in-human, Open-label, Multicenter Study to Investigate the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of SIM0505 in Adult Participants With Advanced Solid Tumors

Phase
Phase 1
Sponsor
NextCure, Inc.
Enrollment
414
Timeline
Feb 2025 → Aug 2028
About This Study

This is an open-label, multicenter phase 1 study to evaluate the safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of SIM0505 in Adult Participants with Advanced Solid Tumors

Eligibility Criteria

Inclusion Criteria

  • 1Written informed consent is obtained prior to any procedures that are not considered standard of care
  • 2≥18 years of age.
  • 3In Part 1:
  • 4Participants with histologically or cytologically confirmed advanced solid tumors, who have failed or are ineligible for standard of care therapies.
  • 5Have progressed on at least one prior systematic anti-tumor regimen, and presence of at least one evaluable lesion according to RECIST Version 1.1. Measurable lesions are required in the backfill period.
  • 6In the backfill period, eligible tumor types are limited to high-grade serous ovarian cancer, high-grade endometrioid ovarian cancer, USC, clear cell RCC, papillary RCC and adenocarcinoma of NSCLC without actionable mutation of epidermal growth factor receptor (EGFR). For participants with NSCLC, presence of CDH6 expression through immunohistochemical examination of tumor tissue by central laboratory is required.
  • 7In Part 2: Participants must have a diagnosis of specific type of metastatic or locally advanced solid tumors and have progressed on or cannot benefit from the most recent systematic anti-tumor regimen (unless otherwise specified), with presence of at least one measurable lesion according to RECIST Version 1.1.
  • 8Platinum-resistant ovarian cancer cohort:
  • 9a. Participants with histologically or cytologically confirmed high-grade serous ovarian cancer, high-grade endometrioid ovarian cancer, primary peritoneal cancer, or fallopian tube cancer.
  • 10Renal cell carcinoma cohort:
  • 11a. Participants with histologically- or cytologically-confirmed clear cell RCC or papillary RCC.
  • 12Uterine serous carcinoma cohort:
  • 13a. Participants with histologically- or cytologically-confirmed USC.
  • 14Non-Small Cell Lung Cancer cohort:
  • 15Participants with histologically- or cytologically-confirmed adenocarcinoma of NSCLC without actionable mutation of EGFR.
  • 16Presence of CDH6 expression through immunohistochemical examination of tumor tissue.
  • 175\. Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1.
  • 186\. Life expectancy of ≥12 weeks. 7. Have adequate organ function as indicated by the laboratory values listed within the protocol.
  • 198\. Women of childbearing potential (WOCBP)must have a negative serum pregnancy test within 72 hours prior to the start of study treatment. WOCBP or male participants are required to use highly effective contraceptive methods , and agree to refrain from donating sperm/egg from signing of informed consent through 180 days after the last dose of study treatment.
  • 209\. Able to provide tumor tissue sample (archival or newly obtained core or excisional biopsy) at biomarker-screening (for NSCLC in both Part 1 and 2) or screening (for non-NSCLC in Part 1) visit of a tumor lesion not previously irradiated for CDH6 testing.

Exclusion Criteria

  • 1For Part 2: has clear cell, mucinous or sarcomatous histology, mixed tumors containing any histology, or low-grade/borderline ovarian cancer; mixed nonsmall cell and small cell carcinoma, or adenosquamous cell lung cancer with an adenocarcinoma component \<50% (the participant is eligible if the adenocarcinoma component is ≥50%).
  • 2Any other malignancy within 2 years prior to the first dose of the study treatment except for localized cancers that are considered to have been cured and in the opinion of the Investigator present a low risk for recurrence.
  • 3Participant has symptomatic central nervous system (CNS) metastases, or CNS metastases requiring CNS-directed local therapy (such as radiotherapy or surgery) or corticosteroids therapy within 2 weeks of first dose of study treatment.
  • 4History of bowel obstruction within 3 months prior to the first dose of study treatment.
  • 5Known psychiatric disorder or drug abuse that would interfere the study requirements.
  • 6Uncontrollable pleural effusion, pericardial effusion, or ascites requiring drainage or medical intervention within 4 weeks before the first dose of study treatment.
  • 7Any active infection requires systemic treatment via intravenous infusion within 2 weeks prior to the first dose of study treatment.
  • 8History of non-infectious pneumonitis that has required a course of oral or intravenous steroids to assist with recovery, or interstitial lung disease (ILD) or severe obstructive pulmonary disease.
  • 9Prior exposure to other CDH6-targeted agents or an ADC with a topoisomerase I inhibitor payload (e.g., raludotatug deruxtecan/DS-6000).
  • 1012\. Major surgery within 2 weeks of receiving the first dose of study treatment.
  • 1113\. Has received prior anti-cancer therapies within the following time frames prior to the first dose of study treatment; Previous cytotoxic therapy, anticancer targeted small molecules (e.g., tyrosine kinase inhibitors), hormonal agents within 2 weeks, Anti-cancer antibody or ADC within 5 half-lives or 4 weeks (whichever is shorter) prior to the first dose of study treatment, Chinese medicines/herbal preparations with anticancer indication taken within 2 weeks and/or Radiation therapy \<4 weeks.
  • 1214\. Use of any live vaccine therapy within 4 weeks prior to the first dose of study treatment.
  • 1315\. Administration of below medications≤14 days prior to the first dose of SIM0505; Strong and moderate CYP3A4 inhibitors and Drugs with known risk of Torsades de Pointes (TdP).
  • 1416\. Known human immunodeficiency virus (HIV) infection or known acquired immunodeficiency syndrome (AIDS).
  • 1517\. Active hepatitis B or hepatitis C infection 18. Participants with clinically significant cardiovascular diseases. 19. History of allogeneic organ transplantation or graft-versus-host disease. 20. Known hypersensitivity to study drug or any of the excipients. 21. Participant is pregnant or breastfeeding. 22. Other conditions that researchers consider inappropriate for inclusion.

Locations

14 sites participating in this study

Emory Winship Cancer Institute

Atlanta, Georgia 30322

Recruiting

Beryl Manning-Geist, MD

Sarah Cannon Research Institute (SCRI) - Lake Nona

Orlando, Florida 32827

Recruiting

Cesar Perez Batista, MD

Dana-Farber Cancer Institute

Boston, Massachusetts 02215

Recruiting

Joyce Liu, MD

Data sourced from ClinicalTrials.govView on ClinicalTrials.gov →